JAK2V617F somatic mutation in the general population: myeloproliferative neoplasm development and progression rate
نویسندگان
چکیده
منابع مشابه
JAK2V617F somatic mutation in the general population: myeloproliferative neoplasm development and progression rate.
Clinical significance of the JAK2V617F mutation in patients with a myeloproliferative neoplasm has been the target of intensive research in recent years. However, there is considerably uncertainty about prognosis in JAK2V617F positive individuals without overt signs of myeloproliferative disease. In this study, we tested the hypothesis that increased JAK2V617F somatic mutation burden is associa...
متن کاملEvaluation of JAK2V617F mutation prevalence in myeloproliferative neoplasm by AS-RT-PCR
Abstract Objective JAK2 is a non-receptor tyrosine kinase that plays a major role in myeloid disorders. JAK2V617F mutation is characterized by a G to T transverse at nucleotide 1849 in exon 12 of the JAK2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the JAK2 protein. Methods In this study we evaluated RNA from 89 pati...
متن کاملCorrelative study between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm.
In this study, we investigated the correlation between the JAK2V617F mutation and thrombosis in patients with myeloproliferative neoplasm (MPN) using real-time fluorescence quantitative PCR. The incidence of thrombus was monitored and blood and coagulation were routinely assayed in patients with MPN. The JAK2V617F mutation was found in 8/68 individuals in the control group (11.8%); it was expre...
متن کاملPrevalence of JAK2V617F Mutation and Its Clinical Correlation in Thais with Myeloproliferative Neoplasm
Original Article AS-PCR JAK2V617F mutation Myeloproliferative neoplasm PCR-RFLP
متن کاملDetection of the JAK2V617F mutation with the Ipsogen MutaScreen kit: absence of JAK2V617F does not mean absence of myeloproliferative neoplasm.
Michael R. Lieber Norris Comprehensive Cancer Center and Departments of Pathology, Biochemistry & Molecular Biology, Molecular Microbiology & Immunology, and Biological Sciences (Section of Molecular and Computational Biology), University of Southern California Keck School of Medicine, Los Angeles, CA Contribution: A.G.T. designed and performed research and wrote the manuscript; A.Y. designed a...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2014
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2014.107631